Endocrine Abstracts

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly occurring if one of the thyroid lobes fails to develop. Due to limited literature data and lack of large-cohort case–control studies, the clinical significance and management with patients in whom TH was diagnosed, are still a matter of debate. The objective of the study was a complex analysis of a large group of patients with TH in comparison to a control group of subjects born with normal, bilobed thyroid ...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly of unclear importance. The aim of the study is to describe clinical, hormonal and autoimmunological profile of patients with TH.Material and methods: The studied group consisted of 20 subjects (4 men), diagnosed of having TH at the age from 15 to 63. Laboratory tests, including measurement of serum concentration of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free tri...

Amiodarone is frequently used in cardiac patients but has side effects which effects the thyroid due to its high iodine content. The use of radioiodine in AIH with low iodine uptake is controversial. In these patients therapeutic choices for refractory cases include either: surgery, antithyroid drugs, or glucocorticosteriods.What are the treatment choices in elderly patients which can’t be operated on, agranulocytosis is present, or have toxic liver...

Introduction: In the etiology of thyroid dysgenesis (TD) an interplay between genetic and environmental factors is thought to play a crucial role. Data from previous studies on association between the season of birth and the incidence of TD causing congenital hypothyroidism (mainly agenesis and ectopy) are conflicting. To date, seasonality of births have not been analysed yet in regard to congenital absence of one thyroid lobe (thyroid hemiagenesis, THA).<p class="abstext"...

Graves disease (GD) is autoimmunological disorder leading most often to hyperthyroidism and invasive-edema opthalmopathy (Graves opthalmopathy – GO).Aim: Estimation of the relation of visual evoked potentials (VEP) results with the indicators of activity and advancement of the progress of GO.Materials and methods: The examined group consisted of 45 patients between the age of 24 and 77, hospitalized in the Department of Endocr...

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves’ orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves’ disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent th...

Introduction: The SAGIT instrument was developed for clinicians to assess the status and evolution of the disease in patients with acromegaly. Currently, it is investigated in the validation phase. The aim of our study was to evaluate the potential utility of SAGIT instrument for distinguishing acromegaly clinical stages and its usefulness in treatment decision-making at a single Polish endocrine center.Patients and Methods: Medical charts of adults with...

Introduction: Radioiodine therapy (RIT) in patients with Graves’ disease (GD) and orbitopathy (GO) is still controversial, especially in smokers, due to the risk of exacerbation of ophthalmologic symptoms.Aim: To evaluate the effect of RIT in smoking and non-smoking patients with mild GO in a 6-month follow-up.Patients and methods: We examined 26 smoking and 25 non-smoking patients, matched for age and gender, presenting hyper...

Introduction: The adipose tissue secrets visfatin, that might have metabolic effect. Changes of visfatin serum concentrations have been observed in different thyroid pathologies. Thyroid hormones affect metabolism, thus, both hypo- and hyperthyroidism might significantly alter body composition.Aims of the study: We aimed to investigate the effect of restoration of euthyroidism on serum visfatin in severe thyroid dysfunction, and its associations with ins...

Introduction: Graves ‘Orbitopathy (GO), is an autoimmune disease associated with Graves’ thyrotoxicosis (GT). The therapy is largely dependent on the severity and activity of ocular changes. Additionally, the severity of GO is influenced by exogenous factors, such as thyroid dysfunction, cigarette smoking or radioiodine therapy (RIT). The aim of the study was to indicate how radioiodine therapy (RIT) influences on GO in smoking and non-smoking patients.<p class="...